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Clinical Testing Through Applied Biochemistry

John Neustadt, ND
Applied biochemistry refers to the concept that metabolic reactions throughout the body determine health and disease and that those metabolic reactions respond to both genetic and lifestyle factors. The concept of biochemical individuality—that each person has unique nutrient and metabolic needs—is foundational to the practice of applied biochemistry.

The concept of applied biochemistry began more than 100 years ago, when Archibold Garrod, MD, described the idea of biochemical individuality in the Lancet in 1902. Roger Williams, PhD, popularized the idea in his 1956 publication, Biochemical Individuality: The Basis for the Genotrophic Concept. Bruce Ames then demonstrated this concept in his lab in Berkeley, CA, by showing that single nucleotide polymorphisms (SNPs) alter enzymatic activity, requiring different levels of cofactors.

Clinical testing of vitamins, minerals, amino acids, fatty acids, hormones, and intermediary compounds of metabolic pathways can help clinicians tailor targeted and individualized treatment plans for their patients. In this discussion, Dr. John Neustadt, ND, shares his insights on the practical applications of clinical testing through applied biochemistry.



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Research Interpretation and Analysis

Joshua Goldenberg, ND
The practice of medicine once relied on the passing down of information from authority figures and the clinical experience of practitioners. The evidence-based medicine (EBM) movement shifted the focus of medical practice to more heavily valued randomized trials and meta-analyses. Clinicians are now expected to be critical evaluators of scientific evidence. The problem is that the evidence base is growing rapidly—there are currently 26 million citations indexed in PubMed alone. In this context, it is no longer practical to expect clinicians to identify, read, and evaluate all of the research related to their field and their patient population. Practice guidelines, meta-analyses, and systematic reviews can be invaluable resources for busy clinicians, but even these publications run the risk of bias. In this discussion, Dr. Joshua Goldenberg, ND, empowers clinicians with skills and tools to critically evaluate current medical evidence.

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