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Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH), hepatic fibrosis, and liver failure. Along with the classic components of metabolic syndrome, the intestinal microbiome might also influence the pathogenesis of NAFLD. Increased intestinal inflammation and permeability are thought to allow the translocation of bacteria and bacterial-derived endotoxins, which stimulate an inflammatory cascade in hepatic tissue.

Ginger (Zingiber officinale) is a common spice worldwide and has a long history of use in Ayurvedic and Chinese Medicine. Traditionally used to quell nausea or soothe digestion, modern science is discovering an array of ways that ginger might improve health. Some research suggests that ginger might modulate blood glucose and lipid levels—offering promise as a therapy for type 2 diabetes or metabolic syndrome.

Dyslipidemia, which can include elevated total cholesterol (TC), elevated low-density lipoprotein cholesterol (LDL-C), elevated triglycerides, or decreased high-density lipoprotein cholesterol (HDL-C), contributes to the pathogenesis of cardiovascular disease. Garlic contains sulfur-containing compounds, which benefit cardiovascular health via numerous mechanisms. Among these mechanisms are antimicrobial, antioxidant, anticoagulant, antihypertensive, and anti-hyperlipidemic actions.

Chronic inflammation is associated with metabolic disorders. More specifically, increased levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor (TNF) are correlated with an increased risk for cardiovascular disease and diabetes. Alpha-lipoic acid (ALA) is an antioxidant nutrient that may reduce inflammation by scavenging free radicals or downregulating pro-inflammatory signaling cascades.