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Hypoglycemic Effect of CoQ10 Supplementation in Type 2 Diabetes: A Meta-Analysis

1/22/2019 4:04:27 PM
Insulin resistance and hyperglycemia characterize type 2 diabetes. Hyperglycemia leads to overproduction of reactive oxygen species, which can lead to mitochondrial damage and impaired mitochondrial oxidation of fats. Coenzyme Q10 (CoQ10) is an antioxidant that can scavenge free radicals and protect mitochondria from oxidative damage. Some studies have reported that patients with diabetes have lower levels of CoQ10 than healthy individuals.
In 2018, a systematic review and meta-analysis updated the pooled evidence on the effectiveness of CoQ10 in type 2 diabetes. A total of 13 randomized controlled trials (including 765 participants) met the inclusion criteria. Study durations ranged from 8 to 24 weeks, with most being 12 weeks. CoQ10 dosage was 200mg per day in almost all studies, with one study using 150 mg and one using 100 mg.
Primary outcome measures were glycosylated hemoglobin (HbA1C), fasting blood glucose, and fasting insulin. Secondary outcome measures were homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, and adiponectin.
Results of the meta-analysis found that CoQ10 significantly decreased HbA1C (weighted mean difference [WMD] = -0.29; 95% CI, -0.54 to -0.03; p=.03) and fasting blood glucose (WMD = -11.21; 95% CI, -18.99 to -3.43; p=.005) when compared with placebo. No significant effects were found for fasting insulin. CoQ10 was also found to decrease triglyceride levels and increase HDL cholesterol.
The studies included in this meta-analysis had an unclear risk of bias, small numbers of participants, and high heterogeneity. None of the studies reported adverse events. Despite these limitations, the authors concluded that CoQ10 might offer some benefits to patients with type 2 diabetes—particularly by supporting glycemic control, triglyceride levels, and HDL cholesterol.
Zhang SY, Yang KL, Zeng LT, Wu XH, Huang HY. Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Int J Endocrinol. 2018.

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