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Cholesterol management continues to be a primary strategy for the prevention of cardiovascular disease. The American Heart Association and the American College of Cardiology recommend statin medications to lower cholesterol in select individuals. However, some patients are intolerant of statin medications, and others choose not to take them. Dietary supplements may offer an alternative approach to cholesterol management for these patients. One such dietary supplement is berberine.

Probiotics may mediate mood and cognition via the gut-brain axis. Human studies have found that probiotics decrease symptoms of depression associated with intestinal disease. Researchers in the Netherlands conducted a randomized controlled trial to assess the effects of a multispecies probiotic on neurocognitive and emotional function.