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Brain injury after ischemic stroke can cause both short-term and long-term debilities. The injurious effects of ischemic stroke can be mitigated by immediate treatment with recombinant tissue plasminogen activator (rt-PA), a serine protease that degrades fibrin clots. The treatment window for rt-PA is narrow, however, and administration after 3 hours of stroke onset can have severe adverse effects, including cerebral edema, disruption of the blood-brain barrier, and intracerebral hemorrhage.

The use of complementary health modalities is common for patients with mental health conditions in the United States, with one study reporting more than 50% of patients with anxiety or depression to have tried a complementary approach within the last year. Naturopathic medicine represents a unique system of healthcare that relies on holistic principles and provides both natural and conventional treatment options. 

Platelet chemokines contribute to the pathogenesis of atherosclerosis by recruiting leukocytes to the site of endothelial injury and by inducing the inflammatory response within atherosclerotic plaques. Furthermore, plasma levels of various platelet chemokines, such as CXCL4, CCL5, CXCL5, CXCL1, CCL2 and CXCL8, are increased in hypercholesterolemia. Reducing platelet chemokines is therefore one feasible approach to reducing the risk of atherosclerosis.

Phytoestrogens are polyphenolic compounds that offer a potential option for managing symptoms of menopause. Isoflavones are a category of phytoestrogens and daidzein is one type of isoflavone. Intestinal bacterian metabolize daidzein into the active equol. It has been suggested that the health benefits of dietary isoflavones depend on individual differences in the ability to produce equol in the intestines—an ability that is generally greater in Asians and in vegetarians. In addition, direct supplementation with equol (10mg/d) has demonstrated benefit for menopausal symptoms in previous clinical trials.

Eating can be an emotional activity. Studies have found, for example, that when people are in a better mood, they choose more nutritious foods. Food can also be used as a form of self-medication to regulate emotions. Chocolate is one of the most commonly craved foods, possibly because of its pleasurable effects on mood. A 2006 study by Macht and Dettmer found that participants experienced a more positive mood after eating a chocolate bar than after eating an apple or nothing at all. Another study found chocolate to be more effective than water at improving mood after watching a sad movie.